Intensive exercise triggers DNA damage associated with the interaction of reactive oxygen and nitrogen. Is diabetes conducive to the deepening of tissue damage or is it not related to this?
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Researchers led by Giuseppe Lippi answered this question. The study involved 19 runners with normal glycemia and 16 diabetics (9 with type 1 diabetes and 7 with type 2 diabetes). They took part in the 21.1 km run. Blood samples were taken and histone H2AX (γ-H2AX) phosphorylation was determined before and 3 h after the run. The emergence of γ-H2AX is associated with DNA damage.
With DNA damage and histone phosphorylation, H2AX binds
Based on γ-H2AX as a marker for double-stranded DNA breaks
Results
The conclusion of DNA damage after running on 21.1 km in diabetes is comparable to that of healthy runners with normal glycemia.
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