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Glutation – a powerful antioxidant

Glutathione is a naturally occurring substance in the cells of all organisms. Considered a “natural guardian of physiology” due to its detoxification properties. Does it, in addition to the role of the chief antioxidant, affect other processes in our body? If you want to find out, I invite you to the following article.

 

  1. What is glutathione?

Glutathione is called the most important antioxidant of the human body. The compound is a tripeptide consisting of amino acid residues of compounds such as cysteine, glycine or glutamic acid. It is worth mentioning that glutathione is a substance that occurs naturally in all plant and animal organisms. It is conditioned by the fact that it is unstable outside the body.

Glutathione is present in most food products that are available on store shelves. However, its largest content is found in fruits and vegetables. In order to increase its level in the body, it is worth enriching your previous menu with products such as

– an avocado;

– broccoli;

– brussels sprouts;

– onion;

– Garlic;

– cabbage;

– turmeric;

– asparagus.

 

  1. Glutation – action

The described tripeptide is primarily an antioxidant. Therefore, its main task is to destroy harmful free radicals and to remove heavy metals such as arsenic, lead or mercury, which get into the body from food and air. Glutation also delays the aging process and the associated consequences – it supports the functioning of the immune system decreasing with age. It is also worth adding that glutathione has a unique feature consisting in the repair of proteins that have been destroyed by free radicals.

In addition to the typical, detoxifying nature, glutathione performs a number of other functions in our body. It participates in the transport of amino acids, is responsible for the production of coenzymes, and is also necessary for the proper functioning and reproduction of lymphocytes. These cells are responsible for the control of pathogenic microorganisms. Furthermore, glutathione is a compound involved in the conversion of hydrogen peroxide into water, which increases the viability of erythrocytes.

Glutation is also recommended for people who lead an active lifestyle. In addition to cleansing the body, it helps maintain adequate muscle strength and a high level of fitness. The overall effect is to improve performance and to reduce the time needed for regeneration. What’s more, glutathione inhibits the activity of cortisol, which is already often described, which at the same time supports the work and synthesis of testosterone.

Another example of the widespread, pro-health nature of glutathione is its importance in the treatment of cancer. In addition to the mentioned antioxidant properties and the production of protective lymphocytes, it has one more feature – it is a natural protection of the body against the harmful effects of chemo-and radiotherapy.

Cancer cells are not able to produce glutathione in contrast to healthy ones. The reduced concentration of substances in sick cells increases their sensitivity to the effects of oncological treatment. In turn, a high level of glutathione in healthy cells weakens the side effects of anti-cancer drugs (including nausea, vomiting, diarrhea or hair loss).

 

  1. Dosage and side effects of glutathione

Due to the very wide access to glutathione, there is no information on the exact doses of supplementation for humans. There is, however, a belief that the use of two servings of 250 mg per day is enough to supplement the daily requirement for this substance. Numerous studies prove that glutathione should be delivered to the body with other substances enhancing its action. We are talking about previously described vitamins B12, C and E.

The risk of glutathione deficiency is real and at the same time very rare due to the prevalence of this substance in many food products. Low level of glutathione in the blood means the pathological state of our body, which testifies to the problems of the body with the removal of free radicals. The result may be digestive problems, decreased immunity and, over time, functional disorders of the internal organs.

 

  1. Opinions

In the medical literature one can come across numerous studies confirming the use of glutathione in the treatment of cancer. First one of them was carried out on a group of thirteen patients with squamous cell carcinoma of the oral cavity.

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Citrulline malate – a real tamer of fatigue

Citrulline malate is one of the supplements that will directly support our effort in training. It belongs to substances that are used for perseverance. Unlike some of them, it is characterized by high effectiveness and scientifically proven activity. See for yourself what citruline malate is and is a real tamer of fatigue!

 

Citrulline malate – what is citrulline malate

Citrulline malate is a combination of citrulline, or amino acid and malic acid, into one molecule. Citrulline is a derivative of another amino acid – ornithine. It is not an amino acid that builds muscle, but it has another important role by participating in the urea cycle, where in the course of metabolism it contributes to the neutralization of toxic ammonia. Malic acid is an organic chemical compound, including in apples and rhubarb. It is a by-product of carbohydrate metabolism. Its ionized form (malate) occurs as an intermediate in the citric acid cycle (Krebs cycle). He also participates in energy transformations taking place in every cell. The combination of both mentioned components into one molecule brings significant benefits for athletes and physically active people.

What does citrulline supplementation give you?

Citrulline malate is seen primarily as a supplement increasing the production of nitric oxide. Thus, it improves blood flow to the trained muscle groups. It gives the effect of the so-called muscle pump. However, it is not the only advantage that gives us supplementation with this compound. In addition to the mentioned effect of nitric oxide production, citrulline malate also intensifies the synthesis of creatine, which in combination with malic acid generates significant energy reserves, resulting in greater muscular and aerobic endurance. Scientific research also shows that the use of citrulline malate may reduce the feeling of fatigue. A positive effect on the renal uptake of bicarbonates was also noted, which improved the overall acid-base balance. One of the very interesting studies showed that the use of citrulline malate was associated with a reduction in the severity of muscle pain. So this supplement made the so-called “Sores” were less noticeable. It is worth adding that citrulline malate works synergistically with various forms of arginine. This combination gives even more effective effects of supplementation. As you can see, supplementation with citrulline malate may have wide applications in supporting the generally understood form of sports.

Citrulline malate – dosage

The best time to take citrulline malate is the peri-exercise period. The recommended dose is 4 – 8 grams per day. You can use monopreparations containing only this compound, but also a good solution may be pre-workout stack supplements, which contains not only citrulline, but also arginine, creatine and stimulants of the central nervous system, such as caffeine, but the dose of citrulline will be a bit smaller.

Citrulline malate is a safe component. There are no undesirable side effects other than the “muscle pump” effect, which may interfere with sport disciplines that require high efficiency and precision. It is recommended only caution in the use of this supplement to people with cardiovascular disease or gastrointestinal dysfunctions.

Citrulline malate – side effects

Cytrulin is one of the three amino acids involved in the urea cycle, and therefore it is an essential amino acid in the body. Even taking daily doses of 15 grams does not cause negative reactions on the part of the digestive system. No side effects were found in the studies. However, caution should be exercised when using drugs to lower blood pressure or potency.