Oxymetholone belongs to one of the most abused SAAs. It has a narrow application in medicine, once anabolic-androgenic steroids were used willingly to support the treatment of various diseases. Their role is currently marginal.
In study men were given oxymetholone for 6 weeks and another 10 acted as a control group. What’s most interesting, the use of anapolon did not have a big influence on triglycerides, total cholesterol, but it changed the amount of LDL-C by 6% and led to a 35% decrease in HDL. Unfortunately, scientists were based on men buying anapolon on the black market, so it is not known whether the substance was in the middle.
In any case, from numerous studies, e.g. 2.3, carried out under better controlled conditions and using drugs from official trade, it appears that anapolon (in a dose of 100 mg per day) affects hemoglobin, creatinine, albumin, bilirubin, ALAT, AST. In addition, it strongly suppresses endogenous testosterone – a decrease of 59.1% in testosterone levels after 24 weeks of administration of 100 mg of anapolone per day. There was a decrease in LH by 37.2% – which explains why anapolon has such a negative effect on the HPTA system.
As you can see, anapolon has an impact on cardiovascular risk, even if it interferes with the lipidogram and significantly increases the amount of hematocrit. The study of Tromsø 4 showed that men with hematocrit (hematocrit = erythrocytes) greater than or equal to 46% have more than 1.5 times the chance of a venous thromboembolism (VTE) and 2.37 times more chance for an unprovoked venous thromboembolism event, compared to men with a hematocrit lower than 43%! And it was not uncommon in studies on SAA that the hematocrit level exceeded 50% (eg, was ~51% after 6 weeks of anapolone use).
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