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Healthcare

Anapolon – is it worth it?

Oxymetholone belongs to one of the most abused SAAs. It has a narrow application in medicine, once anabolic-androgenic steroids were used willingly to support the treatment of various diseases. Their role is currently marginal. 

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In study men were given oxymetholone for 6 weeks and another 10 acted as a control group. What’s most interesting, the use of anapolon did not have a big influence on triglycerides, total cholesterol, but it changed the amount of LDL-C by 6% and led to a 35% decrease in HDL. Unfortunately, scientists were based on men buying anapolon on the black market, so it is not known whether the substance was in the middle. 

In any case, from numerous studies, e.g. 2.3, carried out under better controlled conditions and using drugs from official trade, it appears that anapolon (in a dose of 100 mg per day) affects hemoglobin, creatinine, albumin, bilirubin, ALAT, AST. In addition, it strongly suppresses endogenous testosterone – a decrease of 59.1% in testosterone levels after 24 weeks of administration of 100 mg of anapolone per day. There was a decrease in LH by 37.2% – which explains why anapolon has such a negative effect on the HPTA system. 

As you can see, anapolon has an impact on cardiovascular risk, even if it interferes with the lipidogram and significantly increases the amount of hematocrit. The study of Tromsø 4 showed that men with hematocrit (hematocrit = erythrocytes) greater than or equal to 46% have more than 1.5 times the chance of a venous thromboembolism (VTE) and 2.37 times more chance for an unprovoked venous thromboembolism event, compared to men with a hematocrit lower than 43%! And it was not uncommon in studies on SAA that the hematocrit level exceeded 50% (eg, was ~51% after 6 weeks of anapolone use).

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You can read also: DHEA – a hormone in tablets

Categories
Healthcare

Weight reduction and the hormonal profile.

The reduction of body weight often causes serious changes in the hormonal profile of both women and men. 

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Researchers measured 11 healthy men

They had a weight of over 100% above the desired body weight. Measurements were made again 5-39 months later after losing weight 26-129 kg and stabilizing the weight with a new body weight. 

 

Results 

The slimming comment caused an average 52.9% increase in the total testosterone, the free testosterone concentration increased by 41.1%. Follicle-stimulating hormone increased by 67.7%, no significant increase in LH. LH is responsible for the synthesis of testosterone in the testes (Leydig cells), and FSH (follicle stimulating hormone) for the synthesis of proteins in Sertoli cells. 

The standards are as follows 

Estradiol norm in serum for a male 10-50 pg / mL, in women it depends on the phase of the cycle and can range from 20 to 750 pg / mL, 

Total testosterone norm is 280-1080 ng / dL (men) and less than 70 ng / dL (women), 

Testosterone free norm> 52 pg / mL (men); % of total testosterone 0.1-0.3%. 

The concentration of total serum testosterone (TT) <8 mmol / L (2.31 ng / mL) or free testosterone (FT) <180 pmol / L (52 pg / mL) requires testosterone replacement regardless of the existence or absence of clinical symptoms hypogonadism 

The conclusions before the reduction were hypogonadism (despite the high free testosterone), after the fat was dropped their total testosterone was already in the norm. Unfortunately, the reduction was not enough to reverse the high estradiol concentration, the concentration of which after slimming was still at the upper limit of the norm – this is an extremely unfavorable situation. 

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You can read also: Negative aspects of low testosterone levels