Enlarged prostate differently prostatic adenoma, or benign prostatic hyperplasia (BPH) affects many men over 45 years of age and significantly annoys their lives. Doctors hurry with the help of prescribing drugs to improve the functioning of the urinary tract and to facilitate urination. Of course, the drugs are effective, but sometimes their use is associated with unpleasant side effects, which should be aware especially that the latest scientific reports say that one of the commonly used drugs may increase the risk of diabetes and impair erection.
Symptoms and treatment of prostatic hypertrophy
Prostatic hypertrophy is caused by hormonal changes in the man’s body with age. This phenomenon often causes urinary retention or other ailments of the lower urinary tract, such as a reduction in the flow of urine, which causes repeated wake up at night for micturition (medical definition of urination). To improve the quality of life, doctors prescribe for men drugs such as alpha blockers, such as Tamsulosin, which relax the smooth muscles of the prostate and improve urination or other drugs, such as Proscar (finasteride) or Avodart (dutasteride), which improve micturition by reducing the volume of the prostate .
What is Avodart?
Avodart is used in men with benign prostatic hyperplasia, i.e. a non-neoplastic prostatic hyperplasia caused by excessive production of a hormone called dihydrotestosterone. The active substance is dutasteride, which belongs to the group of 5-alpha reductase enzyme inhibitors.
Side effects of taking Avodart
The treatment of benign prostatic hyperplasia (BPH), the widely prescribed drug Avodart (dutasteride) according to a study recently published in the journal Hormones Molecular Biology and Clinical Investigations may cause an increased risk of diabetes, elevated cholesterol, non-alcoholic liver disease and increasing erectile dysfunction.
Physicians should be fully aware of the latest discoveries of scientific research. Their duty is to make the patient aware and discuss with him the potential consequences of using this preparation, which, as it turns out, can lead to impairment of metabolic and sexual activities.
What do the scientists say?
Professor Traish biochemistry and urology from the Boston School of Medicine (BUSM) says the following: We believe our findings suggest that Avodart has a negative effect on men’s general health because it increases glucose and glycated hemoglobin in the blood, and increases the concentration of lipids. Increased blood glucose and HbA1c levels may predispose men to diabetes, and lipid increases may predispose them to non-alcoholic steatohepatitis (NAFLD). Most importantly, this factor worsens sexual function and reduces the quality of life.
Which drug seems safer?
The study mentioned by the professor included one group of men with BPH who received Avodart and a second group who were prescribed Tamsulosin (alpha blocker). Both groups were looked after for 36-42 months. Blood glucose, glycosylated hemoglobin, total cholesterol, LDL and HDL cholesterol, and liver enzymes were determined at each visit. Participants also completed questionnaires to assess the quality of life and the international index of erectile function to assess their sexual activity. Data for men from the Avodart group were compared with those of men taking Tamsulosin.
Researchers at BUSM believe that data obtained as a result of this study and reports published by other scientists conducting animal models and clinical trials suggest that Avodart can cause serious undesirable side effects that were not obvious a few years ago. In order to reduce the negative impact on health and quality of life, doctors should discuss with patients the potential adverse side effects of taking Avodart, Professor Traish said.
This text aims to increase the awareness of people in the risk group as well as everyone interested in the topic that is common and we should not be ashamed to speak about it. Talking to your doctor about the best treatment is our privilege and we can not be embarrassed by asking for it. Conscious patients motivate physicians to learn about the most effective methods of help, which is always good for everyone.