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  Does nandrolone affect homocysteine ​​levels?

According to some studies, homocysteine ​​is an important health marker. 

Exogenic (external) factors that cause hyperhomocysteinemia belong to 

Anabolic steroids can affect the absorption of vitamins B6 and B12 – and thus can lead to an increase in the level of homocysteine. Why? Homocysteine ​​metabolism also depends on 2 vitamins B6 and B12 as cofactors. This explains why taking SAA can increase the level of homocysteine. 

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Researchers checked whether nandrolone decanoate had an effect on homocysteine ​​levels in rats. They were given a gigantic dose of 3 and 10 mg / kg body weight nandrolone decanoate by weekly intramuscular injections. Animals from the control group received a solvent from nandrolone decanoate. After 14 weeks, the total plasma homocysteine ​​level was measured. In order to ascertain the adequacy of doses and the bioavailability of nandrolone, testicular parameters were also studied. While the functions of the nuclei were significantly suppressed, no relationship was found between the administration of nandrolone decanoate and the total homocysteine ​​concentration. Thus, factors other than plasma homocysteine ​​levels may contribute to an increased incidence of cardiovascular events following chronic use of anabolic-androgenic steroids. 

Nandrolone does not have to cause hyperhomocysteinemia – however, it has other, proven negative effects on the human system (including the structure of collagen fibers). In addition, higher SAA doses have a negative effect on the functioning of the circulatory system and kidneys. 

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You can read also: How does vitamins become active?

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Healthcare

Vitamin B5 strengthens the immune system.

A significant but not ridiculously high dose of vitamin B5 makes the immune system more aggressive towards Mycobacterium tuberculosis tuberculosis bacteria. This is suggested by an animal study that Chinese immunologists from the University of Guangzhou have published in Frontiers in Immunology. 

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Researchers experimented with mice by placing 200 bacteria of the M37R strain in their lungs, the M. tuberculosis H37Rv. Mycobacterium tuberculosis strain H37Rv is a variant of TB bacteria with which scientists have experimented since the beginning of the 20th century. The estimated dose of vitamin B5 was 500-700 mg. This is not a very high dose. In most online stores with supplements you can easily get those that contain 500 mg in a capsule. 

After four weeks, researchers investigated that there are fewer TB TB bacteria in the lungs of mice. In contrast to the control group, which was not given vitamin B5. How the vitamin B5 works on tuberculosis bacteria scientists discovered when they examined the immune cells in the blood of mice. Vitamin B5 did not increase the number of immune cells, but caused CD4-T cells to produce more cytokines, such as interleukin-17 and interferon-gamma. 

In conclusion, research suggests that orally administered vitamin B5 significantly inhibits the growth of Mycobacterium tuberculosis by regulating innate and adaptive immunity. It can therefore have therapeutic properties in the clinical treatment of tuberculosis. 

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You can read also: P5P – highly bioavailable form of vitamin B6

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Healthcare

Diet for rheumatoid arthritis, RA – what to eat? Products recommended

  1. Vegetables and fruits – the diet of a person with inflammatory disease should be based on vegetables and fruits, every day should eat 500-700 g of vegetables and 300-500 g of fruit.They are foods very rich in vitamins, minerals and antioxidants. , eg polyphenols, carotenoids. A vegetable-based diet has a strong anti-inflammatory potential and is effective in treating many diseases with chronic inflammation.
  2. Greasy sea fish – salmon, mackerel, herring, sardines, tuna and other sea fish provide omega-3 fatty acids with a strong anti-inflammatory effect, which is not enough in the average diet. Numerous studies show that omega-3 intake reduces the number of swollen joints and their painfulness, shortens the morning stiffness of the joints, increases the time to fatigue after waking up and increases the strength of the grip, and generalizing – reduces the activity of the disease.The use of fatty fish at least twice a week and supplementation of omega-3 fatty acids is of key importance to reduce the symptoms and behavior of the disease.
  3. Whole grains – groats, rice, cereals, and wholemeal bread are a source of fiber. Research on the effectiveness of fiber in reducing markers of inflammation in the blood are ambiguous. The digestive tract is very important in terms of health, therefore it is worth including it in the diet.
  4. Legume seeds – provide fiber, mineral salts and anti-oxidants with anti-inflammatory effect.

Fish Oil 1000mg

Best products at RA

  • olive oil
  • contains monounsaturated fatty acids effective in calming inflammation in the body and oleocanthal – a compound that gives a burning, bitter aftertaste when consuming oil.
  • scientific evidence has shown the important role of oleocanthalu in reducing markers of inflammation and its effectiveness in the treatment of diseases involving degeneration of joints.
  • coriander, turmeric,
  • ginger, cinnamon
  • they are rich in various bioactive compounds with anti-inflammatory effects.
  • have the ability to relieve the symptoms of RA and reduce the levels of markers of inflammation, as demonstrated in animal studies.
  • Bromelain from pineapple
  • is located mainly in a gulp of pineapple, which is inedible, so the source of bromelain can be high-quality dietary supplements.
  • in scientific research, it is suggested that appropriate formulations may even replace non-steroidal anti-inflammatory drugs.
  • green tea contains a powerful EGCG antioxidant that inactivates proinflammatory proteins.
  • dark fruit cherries, berries, raspberries, pomegranate, blackcurrant are rich in anthocyanins with antioxidant and anti-inflammatory effects.
  • parsley contains flavonoid luteolin with action blocking proinflammatory proteins.

Nutritional deficiencies in rheumatoid arthritis

In one study, the analysis of the diet of 52 women with RA showed an insufficient intake of omega-3 fatty acids, and thus – a highly disturbed ratio of fats n-6 / n-3.Their menus were also low in folic acid, vitamin D, potassium and calcium.These food components are among the most deficient among people suffering from rheumatoid arthritis.Nutritional deficiencies in this disease are closely related to the type of drugs used.NSAIDs increase the permeability of the small intestinal mucosa, vascular inflammation, secondary anemia and excessive protein loss.Particularly important nutrients are iron, folic acid, vitamin C, B6 and B12.Steroids have a negative effect on skeletal status, therefore, when taking them, a calcium-rich diet is recommended (which does not come from dairy products but, for example, from broccoli and dried figs) and vitamin D. Methotrexate is a folic acid antagonist, hence the number of products should be increased in the diet. rich in this component, whereas methotrexate in combination with sulfasalazine increases the concentration of homocysteine ​​in the blood, and this translates significantly into a greater risk of cardiovascular disease. The diet should then be enriched with omega-3 fatty acids, vitamins B6 and B12 and folic acid.

Rheumatoid arthritis diet, RA – contraindicated products

People suffering from rheumatoid arthritis first of all have to eliminate very strong pro-inflammatory trans fats from the diet. They are found in hard margarines, shop sweets, donuts, buns, fast food, broth cubes and some ready-made dishes. high-processed food must be excluded.

Sugar and alcohol are also inadvisable. The results show a relationship between the severity of RA and the frequency of alcohol consumption. The diet should pay attention to reducing the consumption of red meat and milk, which many people are intolerable.

There are no conclusive studies indicating the negative impact of dairy consumption on the course of the disease, but the analysis of individual cases allows to conclude that dairy products actually enhance the symptoms of RA.

Other products that you need to limit it fried and grilled foods – products prepared in this way at a high temperature are turning brown, which is a typical process called Maillard reaction. The very harmful chemicals created during this reaction are final glycation products (AGE). There is no conclusive evidence of AGE association with RA, no however, he has doubts that these compounds intensify the inflammation in the body, so it is worth replacing frying at least 3-4 times a week for cooking, stewing and baking

allergenic and intolerant products – due to the increased permeability of the intestinal epithelium, the food causing allergies and food intolerances is even more harmful than in the case of healthy people, as it easily penetrates into the blood and stimulates the immune system, which in turn increases inflammation.In the case of RA, it is worth performing tests for allergies and food intolerances and a diet that eliminates problematic products.

nightshade vegetables – tomato, pepper, potato and eggplant can be problematic due to the content of alkaloids. Whether or not they exacerbate RA is a very individual and challenging issue.It is worth eliminating nightshade for 2 weeks from the diet and observe if the symptoms of the disease are less severe.Then eat them again, analyzing if the pain and swelling of the joints is getting worse

nuts and seeds are a contentious issue because they are very nutritious. At the same time, however, they are a source of omega-6 fatty acids, whose average diet provides too much.Nuts and seeds rich in omega-6 are peanuts (which are not botanically nuts), almonds, sesame, pumpkin and sunflower seeds.Their amount should be controlled in the diet.

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You can read also: The diet has a huge impact on the resolution of the symptoms of rheumatism

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Healthcare

Millet – properties and application

Millet (common millet, millet appropriate) is a cereal whose grain has numerous properties and nutritional values, which is why it has found many uses: millet is a gluten-free cereal, therefore it can be consumed by people with celiac disease and gluten intolerance a source of B vitamins, beneficial polyunsaturated fatty acids and antioxidants What health action does piglet have? What has been found in the kitchen? What is being done with it?

Millet (common millet, millet appropriate, Panicum miliaceum L.) is a cereal whose seeds have long been known to humanity. Its properties and nutritional values ​​were appreciated in ancient China, from where millet came to Europe and America. , and in developed countries, it is mainly used as animal feed.

Millet is a cereal rich in protein, which is the source of essential amino acids

Methionine and cysteine. Millet is also characterized by a high content of polyunsaturated fatty acids, dietary fiber and polyphenols. Millet is rich in complex carbohydrates. Consumption of a meal with the use of millet gives energy for a longer time, causing a gradual release of energy and increases the feeling of satiety. Millet is therefore an excellent choice for people who are slimming and who want to maintain a healthy weight.In addition, the cereal is rich in copper, phosphorus and iron. In addition, it contains significant amounts of B vitamins.

Millet

  • is a grain without gluten, which is why it is a great option for people suffering from celiac disease and gluten intolerance
  • reduces cholesterol, stabilizes blood glucose levels due to the presence of dietary fiber (beta-glucan)
  • has a positive effect on the digestive system, facilitating defecation
  • thanks to the presence of phosphorus, zinc and vitamins from group B has a positive effect on the circulatory system
  • strengthens the walls of blood vessels and lowers blood pressure,
  • Antioxidant compounds contained in it protect against free radicals – they protect DNA against damage and prevent the formation of cancer cells
  • thanks to high non-heme iron content has a positive effect on the formation and functioning of red blood cells, prevents the onset of anemia, which is associated with cognitive, immune and digestive disorders
  • helps to keep the blood glucose level constant, which prevents the onset of diabetes, metabolic syndrome
  • it reduces the level of glucose in the blood and decreases insulin resistance in diabetics, it also reduces postprandial glycemia
  • thanks to its alkaline properties it helps to maintain the acid-base balance in the body
  • accelerates wound healing and prevents tissue damage
  • it has a probiotic effect – it supports the intestinal microflora and supports its re-colonization by bacteria. Fermented millet products act as natural probiotics in people with diarrhea