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Leptin

Obesity is undoubtedly one of the most dangerous diseases of civilization. The number of obese people is increasing year by year at an alarming rate. This makes scientists more and more often wonder about its causes. It turns out that often it is not just the intake of too many calories and poor will to a significant increase in body weight. Recent research indicates that leptin, and more specifically, lung resistance, maybe one of the main factors leading to an increase in human body fat.

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What is leptin and what is its action?
Leptin is a hormone produced almost exclusively by adipocytes. The concentration of leptin circulating in the blood is directly proportional to the amount of adipose tissue. Its main task is to provide information to the brain about body fat resources and regulation of appetite and satiety. This happens with the help of receptors located in the hypothalamus. The scheme of operation seems simple. The more we eat, the more fat cells are in our bodies. Large amounts of leptin are produced, which, by sending signals to the hypothalamus, suppress the appetite center. When we do not take food, the level of fat decreases, and thus – leptin production also decreases. Low hormone concentration is a warning to the body against exhausting energy reserves, the center of hunger is stimulated. This type of mechanism is called negative feedback and is very often used to regulate other physiological functions such as breathing, maintaining proper body temperature or blood pressure. This system should protect us both from eating too much food and long-term starvation. So what makes it stop functioning properly and we start with you?
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Leptin resistance and obesity
Obese people have a lot of body fat in their body that produces very much leptin. Considering the mechanism of action of the hormone, such persons should not consume excess food, their brain should be informed that there is enough adipose tissue. So why is not this happening? The problem is that the signal is not picked up. Although huge amounts of leptin circulating in the bloodstream, the brain can not read its presence. This makes the brain mistakenly thinks that the body is in a state of hunger and activates processes related to increasing food intake and minimizing energy expenditure. This condition is called resistance to leptin and is indicated as one of the main biological determinants of obesity.

Why the diet does not work?

People who lose weight often face the problem of recurring kilograms. The effects of weight loss are rarely long-term. The reasons for this phenomenon may be many, but it is pointed out that the labyrinth may also be responsible for it. During rapid, rapid weight loss, hormone levels drop drastically. It is a signal for the brain that the amount of spare energy material has decreased significantly, which is why it begins to protect the adipose tissue with the use of biochemical forces that force us to eat. Perhaps that is why perseverance on the diet is so difficult for some people.

What are the causes of leprosy resistance and how to prevent it?
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Research has identified several biological mechanisms that may be responsible for the development of leptin resistance. These include inflammation, high levels of free fatty acids in the blood and high leptin levels. It is not difficult to notice that all these factors are also widely recognized as increasing the risk of obesity. A vicious circle is formed in which obese people become more resistant to leptin, resulting in even greater accumulation of adipose tissue.

So what can we do to prevent this from happening? Below are some tips

– avoid processed food,

– eat products rich in fiber,

– enable regular physical activity,

– sleep out,

– take care of the appropriate level of triglycerides in the blood,

– eat products rich in wholesome protein.

All the above practices have a proven positive effect on reducing chronic inflammation in the body and are the key to preventing leptin resistance and even regressing it. Of course, achieving a long-lasting effect is not easy, it requires a lot of determination and introduction of permanent, often big changes in lifestyle.

Summary

Obesity is not always caused by laziness and lack of strong will. There are also many strong biological conditions involved, and one of the most important is the regulation of hunger and satiety by leptin. However, it should be remembered that how we live and what we eat has a huge impact on our bodies. An improper diet can disrupt properly functioning mechanisms for centuries, and a return to a correct condition becomes even more difficult.
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Healthcare

Unrefined slimming increases the risk of food shortages

Bringing a slimming diet only to the level of energy balance and ensuring adequate supply of protein is a fairly popular practice that can be found on online forums. In accordance with the conventions in force during the reduction of body fat, it is recommended to introduce a caloric deficit, increase protein intake and, depending on the school, reduce the share of energy from fat or carbohydrates. 

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While these types of solutions can be effective in the context of reducing body fat, they are not always good for health. Many people, unfortunately, do not attach enough importance to ensuring sufficiently high intake of all nutrients needed for the proper functioning of the body, exposing themselves to nutritional deficiencies.

 

For the proper functioning of the human body, we need not only an adequate supply of energy, but also several dozen different components performing various physiological functions, including among others vitamins, essential fatty acids, exogenous amino acids, minerals. Although the organism in the course of evolution has developed the ability to deal with over-supply situations and shortages of the required compounds, its adaptation possibilities are limited in this respect. The prolonged deficiency of a nutrient results in disruption of homeostasis and abnormal course of selected metabolic reactions, and may even lead to serious illness or – death. 

In modern times, fortunately, deep nutritional deficiencies in civilized countries are rare, but more often it is possible to meet situations in which the scale of the deficit of a given component is small or moderate. The health consequences of such a state are not sudden, but they are mild, spread over time, which – unfortunately – is difficult to diagnose … more 

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You can read also: Diet and exercise as one of the main ways to lose body fat

 

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Healthcare Strengthen immunity

The influence of adipose tissue on the development of tumors

I suspect that everyone once wondered about the consequences of having extra kilos. Visual aspects come to mind at first. We all know that we want to look and feel good in our own body, and excess fat is not associated with something attractive. However, not what you see from the outside, and the interior of our body should worry us. Scientific research shows that the health consequences caused by excessive amount of this unwanted tissue are many.

A study published in the Cancer Prevention Research, a scientific journal of the American Association for Cancer Research, showed that adipose tissue can affect the development of cancer in many ways. Depending on the type of fat and its location in the body. The main author of the study Dr. Cornelia M. Ulrich, director of population sciences at the Huntsman Cancer Institute at the University of Utah in Salt Lake City, according to the doctor

Obesity is increasing dramatically all over the world and is currently considered one of the main risk factors for obesity-related cancers that currently distinguish as many as 16 types. Urgently, we need to identify specific mechanisms that connect obesity with cancer.

Other studies also confirm the thesis of the latest discovery. As it turns out, there are many mechanisms and ways that lead from fat to cancer. One of them is the inflammatory organism that has long been associated with cancer and in the first place with obesity. In addition, obesity adversely affects the metabolism of cancer cells and immunity, which can lead to the growth and spread of cancer cells. Several studies have shown that some fat cells contribute to the growth of tumors. These cells were more common in obese people suffering from prostate cancer and breast cancer.

A review study by Dr. Ulrich showed that some types of adipose tissue are more \ metabolically active \ and therefore they secrete more substances that affect the development of cancer. In the human body we can distinguish three types of adipose tissue: white, brown and beige. Each of them has a different role and occurs in a different amount depending on the area of ​​the body. The review found that white adipose tissue was associated with increased inflammation, while in patients with breast cancer correlated dadatnio with worse prognosis.

Dr. Ulrich analyzed the effect of fat cells on breast, colon, esophagus, cervical cancer and prostate cancer, considering the proximity of adipose tissue to organs. For example, in the case of colorectal cancer, adipose tissue is located adjacent to tumors, while in breast cancer, adipose tissue forms part of the direct microenvironment of the cancer.

Of course, research in this direction will continue. However, it can already be concluded that excess fat increases the risk of cancer. Regardless of whether it is an excess of subcutaneous or intraperitoneal fat, the risk of developing cancer increases. The organ-to-body fat is so much more dangerous that it is not visible to the naked eye, so that people who have it can be completely unaware. That is why it is so important to watch a healthy menu and regular physical activity. It is not enough to be slim (skinnyfat is a type of bad health) should be taken into consideration skeletal muscle strengthening while caring for a sufficiently low level of body fat.