Can probiotics help people fight the Chronic Fatigue Syndrome?

In recent times, more and more are being said and written about the unique properties of microorganisms colonizing our intestines. It turns out that some of the bacteria that live there have a decisively beneficial effect on the functioning of the human body, but their range goes far beyond the intestinal ecosystem reaching even very distant tissues, systems and organs. Recent studies indicate that the condition of the intestinal microflora may be related to the functioning of the nervous system and our mental condition. Currently, the possibility of using preparations containing probiotic bacteria in the treatment of Chronic Fatigue Syndrome is intensively studied. 


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Fatigue is a condition that each of us feels at least several times a day. Work, study, training, home chores, driving a car, talking on the phone, and even a complete lack of physical and mental activity can at some point lead to feelings of tiredness. Sometimes, however, the condition of chronic exhaustion lasts for weeks or even months and does not subside after rest and an attempt to relax. We probably have to deal with the Chronic Fatigue Syndrome (CFS). The etiology of this condition is not fully understood, there are relatively many concepts to explain the mechanisms of CFS development, some of them suggest an indirect correlation with the condition of the intestinal microflora. 

In a four-year, double-blind, controlled pilot study, a group of Canadian scientists decided to give CFS patients two months to administer a preparation containing 24,000,000,000 Lactobacillus casei strains of Shirota (LcS) to assess their therapeutic effects. It turned out that this treatment brought a clear improvement in the participants randomly assigned to the drug group, in the absence of any effects in the placebo group. 


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Citrulline malate – a real tamer of fatigue

Citrulline malate is one of the supplements that will directly support our effort in training. It belongs to substances that are used for perseverance. Unlike some of them, it is characterized by high effectiveness and scientifically proven activity. See for yourself what citruline malate is and is a real tamer of fatigue!


Citrulline malate – what is citrulline malate

Citrulline malate is a combination of citrulline, or amino acid and malic acid, into one molecule. Citrulline is a derivative of another amino acid – ornithine. It is not an amino acid that builds muscle, but it has another important role by participating in the urea cycle, where in the course of metabolism it contributes to the neutralization of toxic ammonia. Malic acid is an organic chemical compound, including in apples and rhubarb. It is a by-product of carbohydrate metabolism. Its ionized form (malate) occurs as an intermediate in the citric acid cycle (Krebs cycle). He also participates in energy transformations taking place in every cell. The combination of both mentioned components into one molecule brings significant benefits for athletes and physically active people.

What does citrulline supplementation give you?

Citrulline malate is seen primarily as a supplement increasing the production of nitric oxide. Thus, it improves blood flow to the trained muscle groups. It gives the effect of the so-called muscle pump. However, it is not the only advantage that gives us supplementation with this compound. In addition to the mentioned effect of nitric oxide production, citrulline malate also intensifies the synthesis of creatine, which in combination with malic acid generates significant energy reserves, resulting in greater muscular and aerobic endurance. Scientific research also shows that the use of citrulline malate may reduce the feeling of fatigue. A positive effect on the renal uptake of bicarbonates was also noted, which improved the overall acid-base balance. One of the very interesting studies showed that the use of citrulline malate was associated with a reduction in the severity of muscle pain. So this supplement made the so-called “Sores” were less noticeable. It is worth adding that citrulline malate works synergistically with various forms of arginine. This combination gives even more effective effects of supplementation. As you can see, supplementation with citrulline malate may have wide applications in supporting the generally understood form of sports.

Citrulline malate – dosage

The best time to take citrulline malate is the peri-exercise period. The recommended dose is 4 – 8 grams per day. You can use monopreparations containing only this compound, but also a good solution may be pre-workout stack supplements, which contains not only citrulline, but also arginine, creatine and stimulants of the central nervous system, such as caffeine, but the dose of citrulline will be a bit smaller.

Citrulline malate is a safe component. There are no undesirable side effects other than the “muscle pump” effect, which may interfere with sport disciplines that require high efficiency and precision. It is recommended only caution in the use of this supplement to people with cardiovascular disease or gastrointestinal dysfunctions.

Citrulline malate – side effects

Cytrulin is one of the three amino acids involved in the urea cycle, and therefore it is an essential amino acid in the body. Even taking daily doses of 15 grams does not cause negative reactions on the part of the digestive system. No side effects were found in the studies. However, caution should be exercised when using drugs to lower blood pressure or potency.

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Vitamin B12 for stress and fatigue

Vitamins are a group of organic chemical compounds that differ not only in the structure but also in the human body. Despite many differences, all have one thing in common – they are necessary for the proper functioning of the body of every human being.

Among the whole range of these compounds is cobalamin – vitamin B12. This text will provide some interesting information about this substance and its impact on our body.

  1. Characteristics of vitamin B12
  2. Application
  3. Operation and properties
  4. Supplementation and effects of deficiency


  1. Characteristics of vitamin B12

Cobalamin is a complex organic compound whose center is cobalt. Vitamin B12, which is soluble in water, is one of the most important minerals of our body. In addition, it participates in many chemical reactions of our system that occur at the cellular level.

To a large extent, cobalamin is synthesized by the natural bacterial flora of our digestive tract. When mentioning the exogenous sources of this compound, first and foremost, meat products, eggs, fish, dairy products and mushrooms are mentioned.


  1. Application

The use of cobalamin is recommended primarily to people on a vegan diet – due to the fact that the primary source of this compound are meat-based products. What’s more, the most important recipients of this substance are also anorectic, alcoholic and elderly people in whom proper nutrition is neglected.

Vitamin B12 is irreplaceable in the context of the proper functioning of the nervous system and the brain. It also increases resistance to stress and has a calming effect, which is used in the fight against bulbs. An additional advantage of this substance is the use in the prevention of mental illness, Alzheimer’s and cancer.


  1. Operation and properties

Vitamin B12, like its “friends” from group B, interacts primarily in protein, fat and carbohydrate transformations. In addition, her activities can be attributed

– synthesis of red blood cells;

– maintaining a mental balance;

stimulation of appetite;

– regulation of the functioning of the nervous system;

– improving mood;

– fusions within cells, mainly bone marrow.

The basic contraindication to the use of vitamin B12 is allergy to this ingredient.


  1. Supplementation and effects of deficiency

The daily dose of vitamin B12 is contained in approximately 1 mg of the preparation. Given dose refers primarily to people exposed to its deficiency, that is vegans and the older part of the population.

It turns out that the consequences of reduced cobalamin concentration are very dangerous. They form a complex disease syndrome that manifests itself with symptoms such as tachycardia, impaired concentration, loss of taste sensation, weakness, unsteadiness of gait, atrophy of the optic nerve, confusion and depression, apathy, irritability and even coma.