We know how alcohol accelerates muscle breakdown!

 

Muscle atrophy is observed in trauma patients, especially after immobilization of the limb in a cast, and in people who abuse alcohol the risk of injury increases and injuries are more serious.

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Check also: Alcohol and mass building or reduction – can you drink on a diet ?

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In this study, it was checked whether alcohol is associated with muscle atrophy or whether it in some way affects the growth of muscle proteins during regeneration after immobilization of the limb. 

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You can read also: Sport and drinking alcohol

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First, atrophy was induced in rats by immobilizing one limb and the other leg was used as a control. Rats were given ethyl alcohol or physiological saline (placebo). In the next trial, the proteasome inhibitor (Velcade) was administered. Finally, one limb was immobilized for 5 days, gypsum was removed and ethyl alcohol or physiological saline (placebo) was administered over 5 consecutive days. Muscle protein synthesis was measured e.g. 4E-BP1 phosphorylation, S6K1 kinase and muscle breakdown markers (eg, mRNA content of MuRF1 ubiquitin ligases and atrogin-1). 

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