Weight reduction and the hormonal profile.

The reduction of body weight often causes serious changes in the hormonal profile of both women and men. 

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Researchers measured 11 healthy men

They had a weight of over 100% above the desired body weight. Measurements were made again 5-39 months later after losing weight 26-129 kg and stabilizing the weight with a new body weight. 

 

Results 

The slimming comment caused an average 52.9% increase in the total testosterone, the free testosterone concentration increased by 41.1%. Follicle-stimulating hormone increased by 67.7%, no significant increase in LH. LH is responsible for the synthesis of testosterone in the testes (Leydig cells), and FSH (follicle stimulating hormone) for the synthesis of proteins in Sertoli cells. 

The standards are as follows 

Estradiol norm in serum for a male 10-50 pg / mL, in women it depends on the phase of the cycle and can range from 20 to 750 pg / mL, 

Total testosterone norm is 280-1080 ng / dL (men) and less than 70 ng / dL (women), 

Testosterone free norm> 52 pg / mL (men); % of total testosterone 0.1-0.3%. 

The concentration of total serum testosterone (TT) <8 mmol / L (2.31 ng / mL) or free testosterone (FT) <180 pmol / L (52 pg / mL) requires testosterone replacement regardless of the existence or absence of clinical symptoms hypogonadism 

The conclusions before the reduction were hypogonadism (despite the high free testosterone), after the fat was dropped their total testosterone was already in the norm. Unfortunately, the reduction was not enough to reverse the high estradiol concentration, the concentration of which after slimming was still at the upper limit of the norm – this is an extremely unfavorable situation. 

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You can read also: Negative aspects of low testosterone levels

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